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Ranya N. Sweis, MD, MS describes the indications for treating severe aortic stenosis with transcatheter aortic valve replacement (TAVR). She shares how the cardiovascular team at Northwestern Medicine continues to evolve TAVR therapies to include high-risk and low-risk patients, additional access points and valve-in-valve procedures. She also discusses the evolution of TAVR clinical trials including active, enrolling clinical trials.