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Eric Ruderman MD shares the research presented at ACR Convergence 2021 in November that looked at rheumatic disease activity following COVID-19 vaccination. He explores whether immunosuppressive medications affect vaccine effectiveness and any contraindications to COVID-19 vaccination for patients with rheumatic disease. Lastly, he discusses the timing or use considerations for immunomodulatory therapy in relation to COVID-19 vaccination and other important considerations for providers caring for patients with rheumatic disease in the COVID-19 era.