We’ve talked frequently on YOU The Owner's Manual Radio Show
about the feminization of male tadpoles when exposed to ponds with plastic bottles made with BPA.
BPA is a plasticizer common in baby bottles in the plastic baby bottle era of 1970 to 2008, and is common in thermal receipts
It acts to disrupt testosterone function and maybe to mimic estrogen. Those changes are thought to be very powerful: it appears male infants function with certain brain structures more like females - more of the FOX2 protein, which leads to more chatter (I kid you not) when the mom has a high blood level of BPA during pregnancy. And more asthma in such children too. Now something even more serious.
Exposure to bisphenol A (BPA) and it’s cousin BPS in the womb or as an infant increases
the risk of childhood learning disorders, by changing the function of a gene important to learning in kids (and even us adults.)
These genes produce a protein that gets chloride out of cells. Not enough chloride out, poor development of connections, which means poor learning.
Small amounts of BPA and BPS seem to interfere with brain development by blocking these genes.
Even worse, maybe this endocrine disruptor is responsible for some of the substantial increase in autism in the last two decades.