One study showed that coronavirus infection in cells and animal tissue induces important NAD+ (nicotinamide adenine dinucleotide)-dependent enzymes, including poly (ADP-ribose) polymerase (PARP), which are a critical part of cells’ innate immune response.
The study also showed that cellular NAD+ levels declined greater than three-fold as a result of coronavirus infection. The findings suggest that replenishing NAD+ levels, which decline under viral infection, may support increased PARP activity and cell survival during the innate immune response to coronaviruses.
Dr. Charles Brenner, Lead Investigator at ChromaDex Corporation, joins Dr. Roizen to explain the significance of these findings.
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